The U.S. - Mexico binational relationship is subject to constant change, challenges, and even uncertainty, from the COVID pandemic to technological changes, or animosity among political leaders. In this environment, institutions today matter more than ever; they provide stability and perspective to the relationship and also help anchor expectations The panel “Institutions Work: The Role of Binational Institutions into Providing Stability and Predictability to the U.S. - Mexico Relationship” served as the CBI’s Second Annual Seminar where experts and practitioners provided an overview of bilateral institutions and an insight on future scenarios from their institutional perspective.